Assay Detail
Functional
CHEMBL5366419
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Olaparib-resistant CAPAN-1 cells assessed as cell proliferation inhibition incubated for 7 days by SRB assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Olaparib-resistant CAPAN-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
YCH1899, a Highly Effective Phthalazin-1(2<i>H</i>)-one Derivative That Overcomes Resistance to Prior PARP Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.58 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5402698 | — | — | 1 | 9.05 |
| CHEMBL5428376 | — | — | 1 | 8.08 |
| CHEMBL5408163 | — | — | 1 | 7.90 |
| CHEMBL5425913 | — | — | 1 | 7.69 |
| CHEMBL5437176 | — | — | 1 | 7.66 |
| CHEMBL5438131 | — | — | 1 | 7.37 |
| CHEMBL5437055 | — | — | 1 | 7.28 |
| CHEMBL5425393 | — | — | 1 | 7.25 |
| CHEMBL5436743 | — | — | 1 | 7.15 |
| CHEMBL5395197 | — | — | 1 | 7.13 |
| CHEMBL5412306 | — | — | 1 | 7.11 |
| CHEMBL5436154 | — | — | 1 | 6.87 |
| CHEMBL5417924 | — | — | 1 | 6.86 |
| CHEMBL5416682 | — | — | 1 | 6.75 |
| CHEMBL5421957 | — | — | 1 | 6.46 |
| CHEMBL5423216 | — | — | 1 | 6.44 |
| CHEMBL5433982 | — | — | 1 | 6.37 |
| CHEMBL5425729 | — | — | 1 | 6.22 |
| CHEMBL5401127 | — | — | 1 | 6.21 |
| CHEMBL3137320 | TALAZOPARIB | 4.0 | 1 | 6.16 |
| CHEMBL5427638 | — | — | 1 | 6.12 |
| CHEMBL5425070 | — | — | 1 | 6.09 |
| CHEMBL5435418 | — | — | 1 | 5.99 |
| CHEMBL5397203 | — | — | 1 | 5.96 |
| CHEMBL5432616 | — | — | 1 | 5.84 |
| CHEMBL5429957 | — | — | 1 | 5.29 |
| CHEMBL5419303 | — | — | 1 | 5.21 |
| CHEMBL5410501 | — | — | 1 | 5.19 |
| CHEMBL5436989 | — | — | 1 | 5.14 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5402698 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL5428376 | — | IC50 | = | 8.28 | nM | 8.08 |
| CHEMBL5408163 | — | IC50 | = | 12.58 | nM | 7.90 |
| CHEMBL5425913 | — | IC50 | = | 20.33 | nM | 7.69 |
| CHEMBL5437176 | — | IC50 | = | 22.14 | nM | 7.66 |
| CHEMBL5438131 | — | IC50 | = | 42.25 | nM | 7.37 |
| CHEMBL5437055 | — | IC50 | = | 52.26 | nM | 7.28 |
| CHEMBL5425393 | — | IC50 | = | 56.4 | nM | 7.25 |
| CHEMBL5436743 | — | IC50 | = | 71.12 | nM | 7.15 |
| CHEMBL5395197 | — | IC50 | = | 73.63 | nM | 7.13 |
| CHEMBL5412306 | — | IC50 | = | 78.15 | nM | 7.11 |
| CHEMBL5436154 | — | IC50 | = | 135.03 | nM | 6.87 |
| CHEMBL5417924 | — | IC50 | = | 137.1 | nM | 6.86 |
| CHEMBL5416682 | — | IC50 | = | 178.48 | nM | 6.75 |
| CHEMBL5421957 | — | IC50 | = | 348.47 | nM | 6.46 |
| CHEMBL5423216 | — | IC50 | = | 363.12 | nM | 6.44 |
| CHEMBL5433982 | — | IC50 | = | 422.95 | nM | 6.37 |
| CHEMBL5425729 | — | IC50 | = | 604.54 | nM | 6.22 |
| CHEMBL5401127 | — | IC50 | = | 617.99 | nM | 6.21 |
| CHEMBL3137320 | TALAZOPARIB | IC50 | = | 686.09 | nM | 6.16 |
| CHEMBL5427638 | — | IC50 | = | 766.42 | nM | 6.12 |
| CHEMBL5425070 | — | IC50 | = | 811.72 | nM | 6.09 |
| CHEMBL5435418 | — | IC50 | = | 1025.99 | nM | 5.99 |
| CHEMBL5397203 | — | IC50 | = | 1108.99 | nM | 5.96 |
| CHEMBL5432616 | — | IC50 | = | 1431.64 | nM | 5.84 |
| CHEMBL5429957 | — | IC50 | = | 5141.44 | nM | 5.29 |
| CHEMBL5419303 | — | IC50 | = | 6148.25 | nM | 5.21 |
| CHEMBL5410501 | — | IC50 | = | 6486.4 | nM | 5.19 |
| CHEMBL5436989 | — | IC50 | = | 7164.59 | nM | 5.14 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 21410.95 | nM | 4.67 |
| CHEMBL5422190 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5404605 | — | IC50 | - | — | - | |
| CHEMBL5427132 | — | IC50 | - | — | - |