Assay Detail
Binding
CHEMBL5366429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP3 (unknown origin) using biotinylated NAD+ as substrate by luminescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP3 (CHEMBL5083) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
YCH1899, a Highly Effective Phthalazin-1(2<i>H</i>)-one Derivative That Overcomes Resistance to Prior PARP Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.11 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5402698 | — | — | 1 | 8.96 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5402698 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 55.4 | nM | 7.26 |