Assay Detail
Binding
CHEMBL5366506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate in presence of ATP measured after 1 hr by ADP-Glo assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Highly Selective and Orally Bioavailable PI3Kδ Inhibitors with Anti-Inflammatory Activity for Treatment of Acute Lung Injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.99 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5395433 | — | — | 1 | 9.52 |
| CHEMBL5405825 | — | — | 1 | 9.10 |
| CHEMBL5415728 | — | — | 1 | 8.85 |
| CHEMBL5415398 | — | — | 1 | 8.80 |
| CHEMBL5396838 | — | — | 1 | 8.80 |
| CHEMBL5423819 | — | — | 1 | 8.74 |
| CHEMBL5187387 | — | — | 1 | 8.70 |
| CHEMBL5401724 | — | — | 1 | 8.59 |
| CHEMBL5397684 | — | — | 1 | 8.59 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 8.54 |
| CHEMBL5433176 | — | — | 1 | 8.51 |
| CHEMBL5425681 | — | — | 1 | 8.43 |
| CHEMBL5439011 | — | — | 1 | 8.40 |
| CHEMBL5438322 | — | — | 1 | 8.37 |
| CHEMBL5414087 | — | — | 1 | 8.17 |
| CHEMBL5406648 | — | — | 1 | 8.03 |
| CHEMBL5401404 | — | — | 1 | 7.97 |
| CHEMBL5422770 | — | — | 1 | 7.95 |
| CHEMBL5412839 | — | — | 1 | 7.93 |
| CHEMBL5408008 | — | — | 1 | 7.92 |
| CHEMBL5425064 | — | — | 1 | 7.76 |
| CHEMBL5434168 | — | — | 1 | 7.39 |
| CHEMBL5430395 | — | — | 1 | 7.38 |
| CHEMBL5435936 | — | — | 1 | 7.33 |
| CHEMBL5395613 | — | — | 1 | 7.14 |
| CHEMBL5403213 | — | — | 1 | 7.14 |
| CHEMBL5394138 | — | — | 1 | 7.08 |
| CHEMBL5409136 | — | — | 1 | 7.06 |
| CHEMBL5427615 | — | — | 1 | 7.03 |
| CHEMBL5404778 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5395433 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5405825 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5415728 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5415398 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5396838 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5423819 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5187387 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5401724 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5397684 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5433176 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5425681 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5439011 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5438322 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL5414087 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL5406648 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5401404 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL5422770 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5412839 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5408008 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5425064 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL5434168 | — | IC50 | = | 40.7 | nM | 7.39 |
| CHEMBL5430395 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5435936 | — | IC50 | = | 46.3 | nM | 7.33 |
| CHEMBL5395613 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5403213 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5394138 | — | IC50 | = | 82.3 | nM | 7.08 |
| CHEMBL5409136 | — | IC50 | = | 87.5 | nM | 7.06 |
| CHEMBL5427615 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5404778 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5439852 | — | IC50 | = | 114.5 | nM | 6.94 |
| CHEMBL3948730 | UMBRALISIB | IC50 | = | 316.0 | nM | 6.50 |