Assay Detail
Binding
CHEMBL5366932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DPP-4 in Caco-2 cells using GP-AMC as substrate by fluorescence based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Long-Acting Dipeptidyl Peptidase-4 Inhibitors: Structural Evolution and Long-Acting Determinants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.32 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650443 | TRELAGLIPTIN | 4.0 | 1 | 8.89 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 1 | 8.28 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650443 | TRELAGLIPTIN | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 16.0 | nM | 7.80 |