Assay Detail
Binding
CHEMBL5366936
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Binding affinity to human DPP-4 using gly-pro-pNA as substrate assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Long-Acting Dipeptidyl Peptidase-4 Inhibitors: Structural Evolution and Long-Acting Determinants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.28 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | 4.0 | 1 | 8.89 |
| CHEMBL3350936 | — | — | 1 | 8.59 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 7.89 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL3350936 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL142703 | VILDAGLIPTIN | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1422 | SITAGLIPTIN | Ki | = | 18.0 | nM | 7.75 |