Assay Detail
Binding
CHEMBL5367006
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NOX1 expressed in CHO cells assessed as inhibition of PMA-induced hydrogen peroxide production pretreated for 15 mins followed by PMA stimulation and measured after 10 mins by Amplex Red based fluorescence analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.51 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | — | 1 | 6.62 |
| CHEMBL301982 | CELASTROL | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL301982 | CELASTROL | IC50 | = | 410.0 | nM | 6.39 |