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Assay Detail

CHEMBL5367028

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human NOX1 transfected in HEK293T cells incubated for 16 hrs and measured after 30 mins by luminol-chemiluminescence based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293T
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

NADPH oxidase 1 (CHEMBL1287628)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors.
Cipriano A, Viviano M, Feoli A, Milite C, Sarno G, Castellano S, Sbardella G.
J Med Chem (2023) 66 : 11632 -11655
PubMed 37650225 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.60 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL407734 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL407734 IC50 = 250.0 nM 6.60