Assay Detail
Binding
CHEMBL5367105
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Inhibition of HDAC6 (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of (S)-N<sup>1</sup>-(thiazol-2-yl) pyrrolidine-1,2-dicarboxamide derivatives targeting PI3Ka/HDAC6 for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.31 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5420057 | — | — | 1 | 8.01 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.92 |
| CHEMBL5439214 | — | — | 1 | 7.58 |
| CHEMBL5418257 | — | — | 1 | 7.55 |
| CHEMBL5406498 | — | — | 1 | 7.42 |
| CHEMBL5438456 | — | — | 1 | 7.41 |
| CHEMBL5400641 | — | — | 1 | 7.35 |
| CHEMBL5422044 | — | — | 1 | 7.28 |
| CHEMBL5410409 | — | — | 1 | 6.89 |
| CHEMBL5410758 | — | — | 1 | 6.82 |
| CHEMBL5435973 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5420057 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5439214 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5418257 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5406498 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5438456 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5400641 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5422044 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5410409 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5410758 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL5435973 | — | IC50 | = | 680.0 | nM | 6.17 |