Assay Detail
Functional
CHEMBL5367107
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Antiproliferative activity against human MCF7 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (S)-N<sup>1</sup>-(thiazol-2-yl) pyrrolidine-1,2-dicarboxamide derivatives targeting PI3Ka/HDAC6 for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.93 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2396661 | ALPELISIB | 4.0 | 1 | 6.60 |
| CHEMBL5439214 | — | — | 1 | 5.91 |
| CHEMBL5420057 | — | — | 1 | 5.76 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.45 |
| CHEMBL5418257 | — | — | 1 | - |
| CHEMBL5438456 | — | — | 1 | - |
| CHEMBL5406498 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2396661 | ALPELISIB | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5439214 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL5420057 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL5418257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5438456 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5406498 | — | IC50 | > | 10000.0 | nM | - |