Assay Detail
Binding
CHEMBL5367111
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Inhibition of HDAC11 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of (S)-N<sup>1</sup>-(thiazol-2-yl) pyrrolidine-1,2-dicarboxamide derivatives targeting PI3Ka/HDAC6 for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.49 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 6.75 |
| CHEMBL5439214 | — | — | 1 | 6.23 |
| CHEMBL5420057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622533 | FIMEPINOSTAT | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5439214 | — | IC50 | = | 586.0 | nM | 6.23 |
| CHEMBL5420057 | — | IC50 | > | 2000.0 | nM | - |