Assay Detail
Functional
CHEMBL5367145
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Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and anticancer activity of N-aryl indolylsulfoximines: Identification of potent and selective anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.09 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405568 | — | — | 1 | 5.89 |
| CHEMBL5412628 | — | — | 1 | 5.80 |
| CHEMBL5421745 | — | — | 1 | 5.77 |
| CHEMBL5437297 | — | — | 1 | 5.70 |
| CHEMBL5427234 | — | — | 1 | 5.00 |
| CHEMBL5405988 | — | — | 1 | 4.41 |
| CHEMBL5419434 | — | — | 1 | 4.40 |
| CHEMBL5409139 | — | — | 1 | 4.40 |
| CHEMBL5411547 | — | — | 1 | 4.40 |
| CHEMBL5413956 | — | — | 1 | - |
| CHEMBL5409364 | — | — | 1 | - |
| CHEMBL5394408 | — | — | 1 | - |
| CHEMBL5427305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405568 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5412628 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5421745 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5437297 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5427234 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5405988 | — | IC50 | = | 38830.0 | nM | 4.41 |
| CHEMBL5419434 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5409139 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5411547 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5413956 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5409364 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5394408 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5427305 | — | IC50 | > | 40000.0 | nM | - |