Assay Detail
Functional
CHEMBL5367412
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Antiproliferative activity against human SW480 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.73 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3183531 | — | — | 1 | 5.97 |
| CHEMBL5432846 | — | — | 1 | 5.95 |
| CHEMBL5423139 | — | — | 1 | 5.74 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.72 |
| CHEMBL5438820 | — | — | 1 | 5.61 |
| CHEMBL5415711 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3183531 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5432846 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL5423139 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL5438820 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5415711 | — | IC50 | = | 4320.0 | nM | 5.37 |