Assay Detail
Functional
CHEMBL5367523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse Ba/F3 EGFR-D770-N771ins_SVD cells incubated for 72 hrs by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Ba/F3 EGFR-D770-N771ins_SVD |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Mechanism and Inhibitors Targeting EGFR Exon 20 Insertion (Ex20ins) Mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.18 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545154 | POZIOTINIB | 3.0 | 1 | 8.57 |
| CHEMBL4802235 | TH-4000E | -1.0 | 1 | 8.14 |
| CHEMBL5409143 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545154 | POZIOTINIB | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4802235 | TH-4000E | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5409143 | — | IC50 | = | 15.0 | nM | 7.82 |