Assay Detail
Functional
CHEMBL5367528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse Ba/F3 EGFR-A763_Y764insFQEA cells incubated for 3 days by Cell Titer-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Ba/F3 EGFR-A763_Y764insFQEA |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Mechanism and Inhibitors Targeting EGFR Exon 20 Insertion (Ex20ins) Mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.53 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 8.57 |
| CHEMBL4650281 | CLN-081 | 3.0 | 1 | 8.30 |
| CHEMBL4650319 | MOBOCERTINIB | 4.0 | 1 | 7.93 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.06 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.67 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4650281 | CLN-081 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4650319 | MOBOCERTINIB | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL939 | GEFITINIB | IC50 | = | 233.0 | nM | 6.63 |