Assay Detail

CHEMBL5367558

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Functional

Antiproliferative activity against human CUTO14 cells harboring EGFR V769_D770insASV mutant incubated for 72 hrs by MTS assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CUTO14
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Structural Mechanism and Inhibitors Targeting EGFR Exon 20 Insertion (Ex20ins) Mutations.

Chen H, Hu S, Patterson AV, Smaill JB, Ding K, Lu X.
J Med Chem (2023) 66 : 11656 -11671
PubMed 37669428 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.14	7.14

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4802235	TH-4000E	-1.0	1	7.14

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4802235	TH-4000E	IC50	=	72.0	nM	7.14