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Assay Detail

CHEMBL5368271

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum 3D7 measured after 3 days by HRP2-ELISA analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Design, synthesis and antiplasmodial evaluation of new amide-, carbamate-, and ureido-type harmicines.
Marinović M, Rimac H, de Carvalho LP, Rôla C, Santana S, Pavić K, Held J, Prudêncio M, Rajić Z.
Bioorg Med Chem (2023) 94 : 117468 -117468
PubMed 37696205 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.31 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 8.52
CHEMBL5427686 1 6.66
CHEMBL5419255 1 6.50
CHEMBL5424232 1 6.48
CHEMBL5397154 1 6.46
CHEMBL5430578 1 6.44
CHEMBL5410260 1 6.41
CHEMBL5395947 1 6.39
CHEMBL5409978 1 6.38
CHEMBL5409572 1 6.38
CHEMBL5429623 1 6.30
CHEMBL5416653 1 6.26
CHEMBL5412627 1 6.19
CHEMBL5431954 1 6.17
CHEMBL5402006 1 6.10
CHEMBL5429242 1 6.01
CHEMBL5422376 1 6.01
CHEMBL5417340 1 5.95
CHEMBL5416548 1 5.91
CHEMBL5421105 1 5.87
CHEMBL269538 HARMINE 1.0 1 5.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 3.0 nM 8.52
CHEMBL5427686 IC50 = 220.0 nM 6.66
CHEMBL5419255 IC50 = 320.0 nM 6.50
CHEMBL5424232 IC50 = 330.0 nM 6.48
CHEMBL5397154 IC50 = 350.0 nM 6.46
CHEMBL5430578 IC50 = 360.0 nM 6.44
CHEMBL5410260 IC50 = 390.0 nM 6.41
CHEMBL5395947 IC50 = 410.0 nM 6.39
CHEMBL5409978 IC50 = 420.0 nM 6.38
CHEMBL5409572 IC50 = 420.0 nM 6.38
CHEMBL5429623 IC50 = 500.0 nM 6.30
CHEMBL5416653 IC50 = 550.0 nM 6.26
CHEMBL5412627 IC50 = 650.0 nM 6.19
CHEMBL5431954 IC50 = 680.0 nM 6.17
CHEMBL5402006 IC50 = 790.0 nM 6.10
CHEMBL5429242 IC50 = 980.0 nM 6.01
CHEMBL5422376 IC50 = 970.0 nM 6.01
CHEMBL5417340 IC50 = 1130.0 nM 5.95
CHEMBL5416548 IC50 = 1240.0 nM 5.91
CHEMBL5421105 IC50 = 1360.0 nM 5.87
CHEMBL269538 HARMINE IC50 = 8250.0 nM 5.08