Assay Detail
Functional
CHEMBL5368276
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against luciferase-expressing Plasmodium berghei infected in human Huh-7 cells assessed as reduction in parasite load preincubated with cells for 1 hr followed by parasite infection and measured after 46 hrs by bioluminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antiplasmodial evaluation of new amide-, carbamate-, and ureido-type harmicines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.43 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397154 | — | — | 1 | 5.64 |
| CHEMBL5427686 | — | — | 1 | 5.54 |
| CHEMBL5416653 | — | — | 1 | 5.47 |
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397154 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL5427686 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL5416653 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL506 | PRIMAQUINE | IC50 | = | 8400.0 | nM | 5.08 |