Assay Detail
Binding
CHEMBL5368325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to PXR (unknown origin) by Lanthascreen TR-FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 1 group I member 2 (CHEMBL3401) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.72 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406315 | — | — | 1 | 6.70 |
| CHEMBL5431862 | — | — | 1 | 6.70 |
| CHEMBL5401472 | — | — | 1 | 6.22 |
| CHEMBL5428009 | — | — | 1 | 5.80 |
| CHEMBL5411199 | — | — | 1 | 5.70 |
| CHEMBL5415064 | — | — | 1 | 5.58 |
| CHEMBL5424811 | — | — | 1 | 5.51 |
| CHEMBL5425250 | — | — | 1 | 5.37 |
| CHEMBL5177096 | — | — | 1 | 5.36 |
| CHEMBL5426305 | — | — | 1 | 5.22 |
| CHEMBL3752911 | — | — | 1 | 4.75 |
| CHEMBL5207330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406315 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5431862 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5401472 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5428009 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5411199 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5415064 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5424811 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5425250 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5177096 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5426305 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3752911 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5207330 | — | IC50 | > | 20000.0 | nM | - |