Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5368327

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to LXR alpha (unknown origin) by Lanthascreen TR-FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Oxysterols receptor LXR-alpha (CHEMBL2808)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1.
Cochran AG, Flynn M.
J Med Chem (2023) 66 : 13116 -13134
PubMed 37702400 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 5.12 5.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5406315 1 5.17
CHEMBL5411199 1 5.07
CHEMBL5428009 1 -
CHEMBL5424811 1 -
CHEMBL5177096 1 -
CHEMBL5415064 1 -
CHEMBL5401472 1 -
CHEMBL5425250 1 -
CHEMBL5431862 1 -
CHEMBL5426305 1 -
CHEMBL3752911 1 -
CHEMBL5207330 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5406315 EC50 = 6700.0 nM 5.17
CHEMBL5411199 EC50 = 8600.0 nM 5.07
CHEMBL5428009 EC50 > 20000.0 nM -
CHEMBL5424811 EC50 > 20000.0 nM -
CHEMBL5177096 EC50 > 20000.0 nM -
CHEMBL5415064 EC50 > 20000.0 nM -
CHEMBL5401472 EC50 > 20000.0 nM -
CHEMBL5425250 EC50 > 20000.0 nM -
CHEMBL5431862 EC50 > 20000.0 nM -
CHEMBL5426305 EC50 > 20000.0 nM -
CHEMBL3752911 EC50 > 20000.0 nM -
CHEMBL5207330 EC50 > 20000.0 nM -