Assay Detail
Binding
CHEMBL5368610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues)/Elongin B/Elogin C (unknown origin) using (FAM)-labeled HIF-1alpha peptide as substrate assessed as dissociation constant by fluorescence polarization assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Von Hippel-Lindau disease tumor suppressor/Elongin B/Elongin C (CHEMBL3301400) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 37 | 6.43 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5421220 | — | — | 1 | 7.43 |
| CHEMBL5403921 | — | — | 1 | 7.28 |
| CHEMBL5425778 | — | — | 1 | 7.20 |
| CHEMBL5398197 | — | — | 1 | 7.14 |
| CHEMBL5422221 | — | — | 1 | 7.10 |
| CHEMBL5416084 | — | — | 1 | 7.07 |
| CHEMBL5423283 | — | — | 1 | 7.01 |
| CHEMBL5405990 | — | — | 1 | 6.95 |
| CHEMBL4225537 | — | — | 1 | 6.89 |
| CHEMBL5425050 | — | — | 1 | 6.87 |
| CHEMBL5424186 | — | — | 1 | 6.85 |
| CHEMBL5413837 | — | — | 1 | 6.83 |
| CHEMBL5395747 | — | — | 1 | 6.79 |
| CHEMBL5412800 | — | — | 1 | 6.79 |
| CHEMBL5416976 | — | — | 1 | 6.74 |
| CHEMBL5430466 | — | — | 1 | 6.73 |
| CHEMBL5412363 | — | — | 1 | 6.66 |
| CHEMBL5414027 | — | — | 1 | 6.61 |
| CHEMBL5418347 | — | — | 1 | 6.55 |
| CHEMBL5422644 | — | — | 1 | 6.53 |
| CHEMBL5405666 | — | — | 1 | 6.52 |
| CHEMBL5401657 | — | — | 1 | 6.49 |
| CHEMBL5435739 | — | — | 1 | 6.48 |
| CHEMBL5423266 | — | — | 1 | 6.40 |
| CHEMBL5404633 | — | — | 1 | 6.30 |
| CHEMBL5397830 | — | — | 1 | 6.28 |
| CHEMBL5398219 | — | — | 1 | 6.05 |
| CHEMBL5420043 | — | — | 1 | 5.98 |
| CHEMBL5402376 | — | — | 1 | 5.90 |
| CHEMBL5410571 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5421220 | — | Kd | = | 37.0 | nM | 7.43 |
| CHEMBL5403921 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL5425778 | — | Kd | = | 63.0 | nM | 7.20 |
| CHEMBL5398197 | — | Kd | = | 73.0 | nM | 7.14 |
| CHEMBL5422221 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL5416084 | — | Kd | = | 86.0 | nM | 7.07 |
| CHEMBL5423283 | — | Kd | = | 97.0 | nM | 7.01 |
| CHEMBL5405990 | — | Kd | = | 112.0 | nM | 6.95 |
| CHEMBL4225537 | — | Kd | = | 129.0 | nM | 6.89 |
| CHEMBL5425050 | — | Kd | = | 134.0 | nM | 6.87 |
| CHEMBL5424186 | — | Kd | = | 141.0 | nM | 6.85 |
| CHEMBL5413837 | — | Kd | = | 149.0 | nM | 6.83 |
| CHEMBL5395747 | — | Kd | = | 163.0 | nM | 6.79 |
| CHEMBL5412800 | — | Kd | = | 162.0 | nM | 6.79 |
| CHEMBL5416976 | — | Kd | = | 183.0 | nM | 6.74 |
| CHEMBL5430466 | — | Kd | = | 186.0 | nM | 6.73 |
| CHEMBL5412363 | — | Kd | = | 220.0 | nM | 6.66 |
| CHEMBL5414027 | — | Kd | = | 245.0 | nM | 6.61 |
| CHEMBL5418347 | — | Kd | = | 281.0 | nM | 6.55 |
| CHEMBL5422644 | — | Kd | = | 297.0 | nM | 6.53 |
| CHEMBL5405666 | — | Kd | = | 305.0 | nM | 6.52 |
| CHEMBL5401657 | — | Kd | = | 322.0 | nM | 6.49 |
| CHEMBL5435739 | — | Kd | = | 330.0 | nM | 6.48 |
| CHEMBL5423266 | — | Kd | = | 397.0 | nM | 6.40 |
| CHEMBL5404633 | — | Kd | = | 496.0 | nM | 6.30 |
| CHEMBL5397830 | — | Kd | = | 528.0 | nM | 6.28 |
| CHEMBL5398219 | — | Kd | = | 883.0 | nM | 6.05 |
| CHEMBL5420043 | — | Kd | = | 1040.0 | nM | 5.98 |
| CHEMBL5402376 | — | Kd | = | 1270.0 | nM | 5.90 |
| CHEMBL5410571 | — | Kd | = | 1450.0 | nM | 5.84 |
| CHEMBL5436460 | — | Kd | = | 2130.0 | nM | 5.67 |
| CHEMBL5433809 | — | Kd | = | 2550.0 | nM | 5.59 |
| CHEMBL5395402 | — | Kd | = | 3920.0 | nM | 5.41 |
| CHEMBL5432818 | — | Kd | = | 4040.0 | nM | 5.39 |
| CHEMBL5408755 | — | Kd | = | 4110.0 | nM | 5.39 |
| CHEMBL5426675 | — | Kd | = | 6240.0 | nM | 5.21 |
| CHEMBL5406835 | — | Kd | = | 8150.0 | nM | 5.09 |