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Assay Detail

CHEMBL5368998

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to biotin tagged hairpin DNA 5'-CGAATTCGTCTCCGAATTCG-3' (unknown origin) by SPR analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Not specified
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and Biophysical and Biological Studies of <i>N</i>-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites.
Nué-Martinez JJ, Cisneros D, Moreno-Blázquez MDV, Fonseca-Berzal C, Manzano JI, Kraeutler D, Ungogo MA, Aloraini MA, Elati HAA, Ibáñez-Escribano A, Lagartera L, Herraiz T, Gamarro F, de Koning HP, Gómez-Barrio A, Dardonville C.
J Med Chem (2023) 66 : 13452 -13480
PubMed 37729094 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 15 5.55 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL534524 1 6.77
CHEMBL5435713 1 6.42
CHEMBL5412472 1 6.26
CHEMBL5415696 1 6.24
CHEMBL5417039 1 6.12
CHEMBL5441079 1 5.50
CHEMBL5429716 1 5.46
CHEMBL5418641 1 5.01
CHEMBL5438251 1 4.63
CHEMBL5423480 1 4.35
CHEMBL5437728 1 4.26
CHEMBL5402794 1 -
CHEMBL5405513 1 -
CHEMBL5415718 1 -
CHEMBL5416121 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL534524 Kd = 170.0 nM 6.77
CHEMBL5435713 Kd = 380.0 nM 6.42
CHEMBL5412472 Kd = 550.0 nM 6.26
CHEMBL5415696 Kd = 580.0 nM 6.24
CHEMBL5417039 Kd = 750.0 nM 6.12
CHEMBL5441079 Kd = 3200.0 nM 5.50
CHEMBL5429716 Kd = 3500.0 nM 5.46
CHEMBL5418641 Kd = 9820.0 nM 5.01
CHEMBL5438251 Kd = 23600.0 nM 4.63
CHEMBL5423480 Kd = 45000.0 nM 4.35
CHEMBL5437728 Kd = 55000.0 nM 4.26
CHEMBL5402794 Kd > 100000.0 nM -
CHEMBL5405513 Kd > 100000.0 nM -
CHEMBL5415718 Kd > 100000.0 nM -
CHEMBL5416121 Kd > 100000.0 nM -