Assay Detail
Binding
CHEMBL5369159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PI3Kgamma expressed in baculovirus infected Sf21 insect cells by ADP-Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Synthesis of 1,3,5-Triazines or Pyrimidines Containing Dithiocarbamate Moiety as PI3Kα Selective Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.70 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 8.49 |
| CHEMBL5436787 | — | — | 1 | 7.48 |
| CHEMBL5408043 | — | — | 1 | 7.46 |
| CHEMBL5399572 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL586702 | ZSTK-474 | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5436787 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5408043 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5399572 | — | IC50 | = | 42.0 | nM | 7.38 |