Assay Detail
Binding
CHEMBL5369243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of biotinylated lipid pocket probes from His-tagged TEAD2 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe addition and measured after 60 mins by TR-FRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcriptional enhancer factor TEF-4 (CHEMBL4523301) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel Compounds as TEAD Inhibitors for Treating Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.38 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419829 | — | — | 1 | 8.52 |
| CHEMBL5401444 | — | — | 1 | 8.52 |
| CHEMBL5422959 | — | — | 1 | 8.40 |
| CHEMBL5400400 | — | — | 1 | 8.40 |
| CHEMBL5416415 | — | — | 1 | 8.22 |
| CHEMBL5415215 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419829 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5401444 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5422959 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5400400 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5416415 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5415215 | — | IC50 | = | 6.0 | nM | 8.22 |