Assay Detail
Binding
CHEMBL5369253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to CDK2/Cyclin E1 (unknown origin) using Ulight-MBP as substrate assessed as inhibition constant preincubated for 30 mins followed by substrate addition measured after 90 mins in presence of ATP by TR-FRET assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 8.57 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446357 | EBVACICLIB | 2.0 | 1 | 9.92 |
| CHEMBL5402601 | — | — | 1 | 9.89 |
| CHEMBL5434470 | — | — | 1 | 9.80 |
| CHEMBL5434780 | — | — | 1 | 9.77 |
| CHEMBL5422841 | — | — | 1 | 9.74 |
| CHEMBL5423838 | — | — | 1 | 9.74 |
| CHEMBL5405526 | — | — | 1 | 9.74 |
| CHEMBL5399918 | — | — | 1 | 9.68 |
| CHEMBL5415273 | — | — | 1 | 9.47 |
| CHEMBL5425198 | — | — | 1 | 9.36 |
| CHEMBL5422107 | — | — | 1 | 9.31 |
| CHEMBL5398255 | — | — | 1 | 9.20 |
| CHEMBL5402758 | — | — | 1 | 9.00 |
| CHEMBL5433947 | — | — | 1 | 8.96 |
| CHEMBL5408374 | — | — | 1 | 8.96 |
| CHEMBL5201870 | TEGTOCICLIB | 2.0 | 1 | 8.85 |
| CHEMBL5429216 | — | — | 1 | 8.68 |
| CHEMBL3655762 | CYC-065 | 2.0 | 1 | 8.64 |
| CHEMBL5428299 | — | — | 1 | 8.19 |
| CHEMBL5399703 | — | — | 1 | 8.10 |
| CHEMBL5440034 | — | — | 1 | 8.06 |
| CHEMBL5403871 | — | — | 1 | 8.05 |
| CHEMBL4112022 | — | — | 1 | 7.96 |
| CHEMBL5401047 | — | — | 1 | 7.89 |
| CHEMBL3298678 | — | — | 1 | 7.80 |
| CHEMBL5427628 | — | — | 1 | 7.77 |
| CHEMBL5409832 | — | — | 1 | 7.15 |
| CHEMBL5404558 | — | — | 1 | 7.06 |
| CHEMBL5438013 | — | — | 1 | 6.62 |
| CHEMBL5403389 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446357 | EBVACICLIB | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL5402601 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL5434470 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL5434780 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL5422841 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL5423838 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL5405526 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL5399918 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL5415273 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL5425198 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL5422107 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL5398255 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL5402758 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5433947 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL5408374 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL5201870 | TEGTOCICLIB | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL5429216 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL3655762 | CYC-065 | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL5428299 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL5399703 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL5440034 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL5403871 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4112022 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5401047 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3298678 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL5427628 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL5409832 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL5404558 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL5438013 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL5403389 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL5428634 | — | Ki | = | 920.0 | nM | 6.04 |