Assay Detail
Binding
CHEMBL5369258
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Binding affinity to ERK2 (unknown origin) using Ulight-MBP as substrate assessed as inhibition constant preincubated for 30 mins followed by substrate addition measured after 90 mins in presence of ATP by TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.67 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3298678 | — | — | 1 | 9.82 |
| CHEMBL5428299 | — | — | 1 | 9.77 |
| CHEMBL5399703 | — | — | 1 | 9.66 |
| CHEMBL4112022 | — | — | 1 | 9.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3298678 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL5428299 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL5399703 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL4112022 | — | Ki | = | 0.36 | nM | 9.44 |