Assay Detail
Binding
CHEMBL5369331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged human recombinant JAK2 (831 to 1132 residues) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 peptide as substrate incubated for 10 mins measured after 90 mins in presence of ATP by caliper mobility shift assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.45 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397400 | — | — | 1 | 6.14 |
| CHEMBL4447181 | LONDAMOCITINIB | 2.0 | 1 | 5.91 |
| CHEMBL5409783 | — | — | 1 | 5.61 |
| CHEMBL5405817 | — | — | 1 | 5.17 |
| CHEMBL5410836 | — | — | 1 | 5.13 |
| CHEMBL5420468 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397400 | — | IC50 | = | 728.0 | nM | 6.14 |
| CHEMBL4447181 | LONDAMOCITINIB | IC50 | = | 1221.0 | nM | 5.91 |
| CHEMBL5409783 | — | IC50 | = | 2431.0 | nM | 5.61 |
| CHEMBL5405817 | — | IC50 | = | 6838.0 | nM | 5.17 |
| CHEMBL5410836 | — | IC50 | = | 7419.0 | nM | 5.13 |
| CHEMBL5420468 | — | IC50 | = | 17544.0 | nM | 4.76 |