Assay Detail
Binding
CHEMBL5369333
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Inhibition of JAK/STAT signaling pathway in human U-937 cells assessed as inhibition of IL-4 stimulated STAT6 phosphorylation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.66 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397400 | — | — | 1 | 7.89 |
| CHEMBL5409783 | — | — | 1 | 7.82 |
| CHEMBL5410836 | — | — | 1 | 7.66 |
| CHEMBL4447181 | LONDAMOCITINIB | 2.0 | 1 | 7.62 |
| CHEMBL5405817 | — | — | 1 | 7.57 |
| CHEMBL5420468 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397400 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5409783 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5410836 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4447181 | LONDAMOCITINIB | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5405817 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5420468 | — | IC50 | = | 42.0 | nM | 7.38 |