Assay Detail
Binding
CHEMBL5369367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK/STAT signaling pathway in human CD14-positive cell monocytes isolated from human PBMC assessed as inhibition of IL-4 stimulated STAT6 phosphorylation preincubated for 20 to 60 mins followed by IL-4 stimulation measured after 15 mins by flow cytometry analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CD14-positive cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.45 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447181 | LONDAMOCITINIB | 2.0 | 1 | 7.70 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447181 | LONDAMOCITINIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 65.0 | nM | 7.19 |