Assay Detail
Binding
CHEMBL5370441
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Agonist activity at TLR7 in human Ramos-blue cells assessed as increase in NFkappaB activation incubated for 72 hrs by quanti-blue/SEAP reporter gene based assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Ramos-Blue |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Optimization of 1-Substituted Imidazo[4,5-<i>c</i>]quinoline TLR7 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 6.64 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5439905 | — | — | 1 | 7.75 |
| CHEMBL5405415 | — | — | 1 | 7.41 |
| CHEMBL5424404 | — | — | 1 | 7.36 |
| CHEMBL5396405 | — | — | 1 | 7.23 |
| CHEMBL5419915 | — | — | 1 | 7.21 |
| CHEMBL5423654 | — | — | 1 | 7.16 |
| CHEMBL5424893 | — | — | 1 | 7.08 |
| CHEMBL5433548 | — | — | 1 | 6.97 |
| CHEMBL5436292 | — | — | 1 | 6.78 |
| CHEMBL5408883 | — | — | 1 | 6.75 |
| CHEMBL5393892 | — | — | 1 | 6.70 |
| CHEMBL5434429 | — | — | 1 | 6.68 |
| CHEMBL5414036 | — | — | 1 | 6.64 |
| CHEMBL5400489 | — | — | 1 | 6.63 |
| CHEMBL5406767 | — | — | 1 | 6.56 |
| CHEMBL5434936 | — | — | 1 | 6.46 |
| CHEMBL5396643 | — | — | 1 | 6.31 |
| CHEMBL5439729 | — | — | 1 | 6.27 |
| CHEMBL383322 | RESIQUIMOD | 2.0 | 1 | 6.21 |
| CHEMBL5433089 | — | — | 1 | 6.08 |
| CHEMBL5436371 | — | — | 1 | 5.88 |
| CHEMBL5399142 | — | — | 1 | 5.87 |
| CHEMBL5414341 | — | — | 1 | 5.75 |
| CHEMBL5408203 | — | — | 1 | 5.69 |
| CHEMBL5418029 | — | — | 1 | - |
| CHEMBL5436701 | — | — | 1 | - |
| CHEMBL5409098 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5439905 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5405415 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5424404 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5396405 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5419915 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5423654 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5424893 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL5433548 | — | EC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5436292 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL5408883 | — | EC50 | = | 176.0 | nM | 6.75 |
| CHEMBL5393892 | — | EC50 | = | 199.0 | nM | 6.70 |
| CHEMBL5434429 | — | EC50 | = | 209.0 | nM | 6.68 |
| CHEMBL5414036 | — | EC50 | = | 231.0 | nM | 6.64 |
| CHEMBL5400489 | — | EC50 | = | 232.0 | nM | 6.63 |
| CHEMBL5406767 | — | EC50 | = | 275.0 | nM | 6.56 |
| CHEMBL5434936 | — | EC50 | = | 344.0 | nM | 6.46 |
| CHEMBL5396643 | — | EC50 | = | 485.0 | nM | 6.31 |
| CHEMBL5439729 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL383322 | RESIQUIMOD | EC50 | = | 616.0 | nM | 6.21 |
| CHEMBL5433089 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL5436371 | — | EC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL5399142 | — | EC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL5414341 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5408203 | — | EC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5418029 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5436701 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5409098 | — | EC50 | > | 30000.0 | nM | - |