Assay Detail
Functional
CHEMBL5370465
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Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 10 days by WST-8 assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Pyrrolo[2,3-<i>c</i>]pyridines as Potent and Reversible LSD1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.54 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436614 | — | — | 1 | 9.22 |
| CHEMBL5410299 | — | — | 1 | 9.15 |
| CHEMBL5410439 | — | — | 1 | 8.82 |
| CHEMBL5405014 | — | — | 1 | 8.77 |
| CHEMBL5436979 | — | — | 1 | 8.57 |
| CHEMBL5422998 | — | — | 1 | 8.54 |
| CHEMBL5408486 | — | — | 1 | 8.49 |
| CHEMBL5407627 | — | — | 1 | 8.39 |
| CHEMBL3134377 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436614 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5410299 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5410439 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5405014 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5436979 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5422998 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5408486 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5407627 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3134377 | — | IC50 | = | 122.0 | nM | 6.91 |