Assay Detail
Binding
CHEMBL5370471
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain cortical membrane GABA alpha receptor by TBPS binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Neurosteroids and Postpartum Depression: The Mechanism, Efficacy, and Approval of Brexanolone and Zurzuvae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.13 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405528 | — | — | 1 | 7.48 |
| CHEMBL5423343 | — | — | 1 | 7.39 |
| CHEMBL5405812 | — | — | 1 | 7.07 |
| CHEMBL3427519 | — | — | 1 | 7.03 |
| CHEMBL5426429 | — | — | 1 | 7.03 |
| CHEMBL5434252 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405528 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5423343 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5405812 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3427519 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5426429 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5434252 | — | IC50 | = | 170.0 | nM | 6.77 |