Assay Detail
Binding
CHEMBL5370737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant COX-2 transfected in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production preincubated for 15 mins followed by arachidonic acid addition and measured after 15 mins by chromogenic assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Clinically approved small-molecule drugs for the treatment of rheumatoid arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.89 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1034 | DICLOFENAC SODIUM | 4.0 | 1 | 8.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1034 | DICLOFENAC SODIUM | IC50 | = | 1.3 | nM | 8.89 |