Assay Detail
Binding
CHEMBL5370855
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Inhibition of EZH1 methyltransferase activity (unknown origin) in PRC2 complex using H3 and 3H-SAM as substrate incubated for 1 hrs by Scintillation proximity assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Recent advances in EZH2-based dual inhibitors in the treatment of cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.36 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197386 | — | — | 1 | 7.68 |
| CHEMBL5197902 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197386 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5197902 | — | IC50 | = | 91.0 | nM | 7.04 |