Assay Detail
Functional
CHEMBL5370872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against promastigote stage of Leishmania infantum MHOM/BR/1974/PP75 infected in human THP-1 cells assessed as parasite growth inhibition incubated for 72 hrs by microplate reader analysis
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hit-to-lead optimization of a pyrazinylpiperazine series against Leishmania infantum and Leishmania braziliensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 4.97 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.60 |
| CHEMBL5407179 | — | — | 1 | 5.72 |
| CHEMBL5402532 | — | — | 1 | 5.55 |
| CHEMBL5436490 | — | — | 1 | 5.54 |
| CHEMBL5437482 | — | — | 1 | 5.51 |
| CHEMBL5397842 | — | — | 1 | 5.48 |
| CHEMBL5406357 | — | — | 1 | 5.48 |
| CHEMBL5416460 | — | — | 1 | 5.46 |
| CHEMBL5396330 | — | — | 1 | 5.35 |
| CHEMBL5396842 | — | — | 1 | 5.29 |
| CHEMBL5418830 | — | — | 1 | 5.28 |
| CHEMBL5398251 | — | — | 1 | 5.24 |
| CHEMBL5414096 | — | — | 1 | 5.21 |
| CHEMBL5426223 | — | — | 1 | 5.14 |
| CHEMBL5400035 | — | — | 1 | 5.12 |
| CHEMBL5430423 | — | — | 1 | 4.97 |
| CHEMBL3431258 | — | — | 1 | 4.92 |
| CHEMBL5428957 | — | — | 1 | 4.85 |
| CHEMBL5394006 | — | — | 1 | 4.80 |
| CHEMBL5416563 | — | — | 1 | 4.66 |
| CHEMBL5429046 | — | — | 1 | 4.60 |
| CHEMBL5419956 | — | — | 1 | 4.58 |
| CHEMBL5430852 | — | — | 1 | 4.56 |
| CHEMBL5434127 | — | — | 1 | 4.46 |
| CHEMBL5431973 | — | — | 1 | 4.45 |
| CHEMBL5402709 | — | — | 1 | 4.36 |
| CHEMBL5428270 | — | — | 1 | 4.26 |
| CHEMBL5398366 | — | — | 1 | 4.23 |
| CHEMBL5438033 | — | — | 1 | 4.20 |
| CHEMBL5412591 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5407179 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5402532 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5436490 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5437482 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5397842 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5406357 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5416460 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5396330 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5396842 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5418830 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5398251 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5414096 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5426223 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5400035 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5430423 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3431258 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL5428957 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL5394006 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL5416563 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL5429046 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL5419956 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL5430852 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL5434127 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL5431973 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL5402709 | — | IC50 | = | 43600.0 | nM | 4.36 |
| CHEMBL5428270 | — | IC50 | = | 55300.0 | nM | 4.26 |
| CHEMBL5398366 | — | IC50 | = | 58800.0 | nM | 4.23 |
| CHEMBL5438033 | — | IC50 | = | 63100.0 | nM | 4.20 |
| CHEMBL5412591 | — | IC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL5429051 | — | IC50 | = | 84500.0 | nM | 4.07 |
| CHEMBL5439730 | — | IC50 | = | 280500.0 | nM | - |
| CHEMBL5438796 | — | IC50 | = | 221000.0 | nM | - |
| CHEMBL5433944 | — | IC50 | = | 141700.0 | nM | - |
| CHEMBL5411027 | — | IC50 | = | 127800.0 | nM | - |
| CHEMBL5425292 | — | IC50 | = | 7431000.0 | nM | - |
| CHEMBL5407537 | — | IC50 | = | 105200.0 | nM | - |
| CHEMBL5413093 | — | IC50 | = | 112700.0 | nM | - |
| CHEMBL5430658 | — | IC50 | = | 175800.0 | nM | - |
| CHEMBL5416541 | — | IC50 | = | 156700.0 | nM | - |
| CHEMBL5430403 | — | IC50 | = | 112500.0 | nM | - |
| CHEMBL1877859 | — | IC50 | = | 122300.0 | nM | - |