Assay Detail

CHEMBL5371114

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Functional

Antiproliferative activity against estradiol-stimulated human MCF7 cells incubated for 48 hrs by CellTiter Glo assay

ChEMBL ↗

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Target

MCF7 (CHEMBL387) ↗

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Primary target MCF7

CHEMBL387

Anchored from Assay target.

Protein identity MCF7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MCF7
Confidence	1 — Organism
Curated By	Autocuration

Target

MCF7 (CHEMBL387) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Selective Estrogen receptor degraders (SERDs) for the treatment of breast cancer: An overview.

Bhatia N, Hazra S, Thareja S.
Eur J Med Chem (2023) 256 : 115422 -115422
PubMed 37163948 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.38	8.38

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4297509	ELACESTRANT	4.0	1	8.38

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4297509	ELACESTRANT	IC50	=	4.2	nM	8.38