Assay Detail
Functional
CHEMBL5371257
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human patient-derived TMZ-resistant GBM cells with MGMT negative P3R cell assessed as inhibition of cell growth measured after 72 hrs by CCK8 method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | P3R cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.72 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426666 | — | — | 1 | 5.84 |
| CHEMBL5423568 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426666 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5423568 | — | IC50 | = | 2530.0 | nM | 5.60 |