Assay Detail
Binding
CHEMBL5371296
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Inhibition of Electrophorus electricus AChE using ATCI as substrate pre-incubated for 10 mins followed by substrate addition measured after 5 mins by microplate reader analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aporphines: A privileged scaffold in CNS drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.14 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456942 | DEHYDRODICENTRINE | — | 1 | 5.96 |
| CHEMBL1171263 | DEHYDROROEMERINE | — | 1 | 5.92 |
| CHEMBL5440844 | — | — | 1 | 5.54 |
| CHEMBL5398483 | — | — | 1 | 5.37 |
| CHEMBL464748 | DICENTRINE | — | 1 | 5.21 |
| CHEMBL5430132 | — | — | 1 | 5.21 |
| CHEMBL483825 | — | — | 1 | 5.08 |
| CHEMBL1989287 | — | — | 1 | 4.98 |
| CHEMBL601020 | STEPHANINE | — | 1 | 4.95 |
| CHEMBL510954 | — | — | 1 | 4.92 |
| CHEMBL1617041 | — | — | 1 | 4.75 |
| CHEMBL5437306 | — | — | 1 | 4.49 |
| CHEMBL5414111 | — | — | 1 | 4.40 |
| CHEMBL469423 | (-)-ASIMILOBINE | — | 1 | - |
| CHEMBL5433445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456942 | DEHYDRODICENTRINE | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL1171263 | DEHYDROROEMERINE | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL5440844 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL5398483 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL464748 | DICENTRINE | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL5430132 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL483825 | — | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL1989287 | — | IC50 | = | 10510.0 | nM | 4.98 |
| CHEMBL601020 | STEPHANINE | IC50 | = | 11340.0 | nM | 4.95 |
| CHEMBL510954 | — | IC50 | = | 11940.0 | nM | 4.92 |
| CHEMBL1617041 | — | IC50 | = | 17630.0 | nM | 4.75 |
| CHEMBL5437306 | — | IC50 | = | 32490.0 | nM | 4.49 |
| CHEMBL5414111 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL469423 | (-)-ASIMILOBINE | IC50 | = | 141470.0 | nM | - |
| CHEMBL5433445 | — | IC50 | = | 147180.0 | nM | - |