Assay Detail
Functional
CHEMBL5371328
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Inhibition of neuronal excitability in mouse Primary neocortical neuron assessed as reduction in SCO amplitude measured after 45 mins by FLIPR assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Primary neocortical neuron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Aporphines: A privileged scaffold in CNS drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.89 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157912 | (S)-BULBOCAPNINE | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157912 | (S)-BULBOCAPNINE | IC50 | = | 12900.0 | nM | 4.89 |