Assay Detail
Functional
CHEMBL5372379
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Cytotoxicity against human HepG2 cells assessed as cell growth inhibition by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic Ergosteroids from a Strain of the Fungus <i>Talaromyces adpressus</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.67 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250639 | DANKASTERONE A | — | 1 | 4.92 |
| CHEMBL5403246 | — | — | 1 | 4.72 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.68 |
| CHEMBL5438899 | — | — | 1 | 4.62 |
| CHEMBL5403122 | — | — | 1 | 4.62 |
| CHEMBL5397524 | — | — | 1 | 4.60 |
| CHEMBL5432128 | — | — | 1 | 4.54 |
| CHEMBL5423265 | — | — | 1 | - |
| CHEMBL5438369 | — | — | 1 | - |
| CHEMBL5439385 | — | — | 1 | - |
| CHEMBL5412420 | — | — | 1 | - |
| CHEMBL5435913 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250639 | DANKASTERONE A | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5403246 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5438899 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5403122 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5397524 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5432128 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5423265 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5438369 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5439385 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5412420 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5435913 | — | IC50 | > | 40000.0 | nM | - |