Assay Detail
Functional
CHEMBL5372397
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Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Reprogramming Energy Metabolism with Synthesized PDK Inhibitors Based on Dichloroacetate Derivatives and Targeted Delivery Systems for Enhanced Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.76 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5440159 | — | — | 1 | 6.57 |
| CHEMBL5289763 | — | — | 1 | 6.55 |
| CHEMBL5403973 | — | — | 1 | 6.16 |
| CHEMBL5405743 | — | — | 1 | 6.03 |
| CHEMBL3290761 | — | — | 1 | 5.96 |
| CHEMBL5419996 | — | — | 1 | 5.78 |
| CHEMBL5402490 | — | — | 1 | 5.72 |
| CHEMBL5439850 | — | — | 1 | 5.71 |
| CHEMBL5419257 | — | — | 1 | 5.68 |
| CHEMBL5424355 | — | — | 1 | 5.60 |
| CHEMBL5422377 | — | — | 1 | 5.60 |
| CHEMBL5423077 | — | — | 1 | 5.59 |
| CHEMBL5394529 | — | — | 1 | 5.50 |
| CHEMBL5417465 | — | — | 1 | 5.49 |
| CHEMBL5423379 | — | — | 1 | 5.48 |
| CHEMBL5436563 | — | — | 1 | 5.45 |
| CHEMBL5423915 | — | — | 1 | 5.43 |
| CHEMBL5425301 | — | — | 1 | 5.33 |
| CHEMBL13960 | DICHLOROACETIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5440159 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5289763 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5403973 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5405743 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3290761 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5419996 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL5402490 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL5439850 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL5419257 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL5424355 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5422377 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5423077 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL5394529 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL5417465 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL5423379 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL5436563 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL5423915 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL5425301 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL13960 | DICHLOROACETIC ACID | IC50 | = | 25000000.0 | nM | - |