Assay Detail
Toxicity
CHEMBL5372398
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Antiproliferative activity against African green monkey COS7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Chlorocebus aethiops |
| Cell Type | COS-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Reprogramming Energy Metabolism with Synthesized PDK Inhibitors Based on Dichloroacetate Derivatives and Targeted Delivery Systems for Enhanced Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.32 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405743 | — | — | 1 | 5.94 |
| CHEMBL5289763 | — | — | 1 | 5.81 |
| CHEMBL5440159 | — | — | 1 | 5.73 |
| CHEMBL5419996 | — | — | 1 | 5.52 |
| CHEMBL5403973 | — | — | 1 | 5.43 |
| CHEMBL5417465 | — | — | 1 | 5.34 |
| CHEMBL5419257 | — | — | 1 | 5.32 |
| CHEMBL5423077 | — | — | 1 | 5.28 |
| CHEMBL5425301 | — | — | 1 | 5.25 |
| CHEMBL5423379 | — | — | 1 | 5.22 |
| CHEMBL5436563 | — | — | 1 | 5.21 |
| CHEMBL3290761 | — | — | 1 | 5.21 |
| CHEMBL5423915 | — | — | 1 | 5.21 |
| CHEMBL5394529 | — | — | 1 | 5.20 |
| CHEMBL5439850 | — | — | 1 | 5.09 |
| CHEMBL5402490 | — | — | 1 | 5.02 |
| CHEMBL5422377 | — | — | 1 | 5.01 |
| CHEMBL5424355 | — | — | 1 | 4.95 |
| CHEMBL13960 | DICHLOROACETIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405743 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL5289763 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL5440159 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL5419996 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5403973 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL5417465 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5419257 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5423077 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL5425301 | — | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL5423379 | — | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL5436563 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL3290761 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL5423915 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL5394529 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL5439850 | — | IC50 | = | 8070.0 | nM | 5.09 |
| CHEMBL5402490 | — | IC50 | = | 9620.0 | nM | 5.02 |
| CHEMBL5422377 | — | IC50 | = | 9660.0 | nM | 5.01 |
| CHEMBL5424355 | — | IC50 | = | 11230.0 | nM | 4.95 |
| CHEMBL13960 | DICHLOROACETIC ACID | IC50 | = | 40000000.0 | nM | - |