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Assay Detail

CHEMBL5372785

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs in DMEM/10% FBS supplemented with galactose by CellTiter-Glo luminescent assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and Structure-Activity Relationships of a New Class of Oxadiazoles Targeting DprE1 as Antitubercular Agents.
Yadav VD, Boshoff HI, Trifonov L, Roma JSO, Ioerger TR, Barry CE, Oh S.
ACS Med Chem Lett (2023) 14 : 1275 -1283
PubMed 37736177 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 4.62 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL211501 ANTIMYCIN A 1 6.92
CHEMBL83 TAMOXIFEN 4.0 1 4.93
CHEMBL5435317 1 4.43
CHEMBL5415141 1 4.43
CHEMBL5397598 1 4.43
CHEMBL5428078 1 4.43
CHEMBL5423235 1 4.43
CHEMBL5407533 1 4.43
CHEMBL5417650 1 4.43
CHEMBL5404541 1 4.43
CHEMBL5429706 1 4.43
CHEMBL5413428 1 4.43
CHEMBL5418701 1 4.43
CHEMBL5411873 1 4.43
CHEMBL5435386 1 4.43
CHEMBL5440519 1 4.43
CHEMBL5426705 1 -
CHEMBL5426120 1 -
CHEMBL5402495 1 -
CHEMBL5416680 1 -
CHEMBL5428397 1 -
CHEMBL5436906 1 -
CHEMBL5427998 1 -
CHEMBL5433120 1 -
CHEMBL5400183 1 -
CHEMBL5425841 1 -
CHEMBL64 ISONIAZID 4.0 1 -
CHEMBL5414809 1 -
CHEMBL5438418 1 -
CHEMBL5404768 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL211501 ANTIMYCIN A IC50 = 120.0 nM 6.92
CHEMBL83 TAMOXIFEN IC50 = 11700.0 nM 4.93
CHEMBL5428078 IC50 = 37500.0 nM 4.43
CHEMBL5435317 IC50 = 37500.0 nM 4.43
CHEMBL5415141 IC50 = 37500.0 nM 4.43
CHEMBL5397598 IC50 = 37500.0 nM 4.43
CHEMBL5423235 IC50 = 37500.0 nM 4.43
CHEMBL5407533 IC50 = 37500.0 nM 4.43
CHEMBL5417650 IC50 = 37500.0 nM 4.43
CHEMBL5440519 IC50 = 37500.0 nM 4.43
CHEMBL5404541 IC50 = 37500.0 nM 4.43
CHEMBL5429706 IC50 = 37500.0 nM 4.43
CHEMBL5413428 IC50 = 37500.0 nM 4.43
CHEMBL5418701 IC50 = 37500.0 nM 4.43
CHEMBL5411873 IC50 = 37500.0 nM 4.43
CHEMBL5435386 IC50 = 37500.0 nM 4.43
CHEMBL5410224 IC50 > 50000.0 nM -
CHEMBL5400518 IC50 > 50000.0 nM -
CHEMBL5425767 IC50 > 50000.0 nM -
CHEMBL5426705 IC50 > 50000.0 nM -
CHEMBL5426120 IC50 > 50000.0 nM -
CHEMBL5402495 IC50 > 50000.0 nM -
CHEMBL5416680 IC50 > 50000.0 nM -
CHEMBL5428397 IC50 > 50000.0 nM -
CHEMBL5436906 IC50 > 50000.0 nM -
CHEMBL5427998 IC50 > 50000.0 nM -
CHEMBL5433120 IC50 > 50000.0 nM -
CHEMBL5400183 IC50 > 50000.0 nM -
CHEMBL5425841 IC50 > 50000.0 nM -
CHEMBL64 ISONIAZID IC50 - -
CHEMBL5414809 IC50 > 50000.0 nM -
CHEMBL5438418 IC50 > 50000.0 nM -
CHEMBL5404768 IC50 > 50000.0 nM -