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Assay Detail

CHEMBL5372969

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]propionyl-pNPY from human Y2R expressed in CHO cells
24
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuropeptide Y receptor type 2 (CHEMBL4018)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

[<sup>3</sup>H]UR-JG102-A Radiolabeled Cyclic Peptide with High Affinity and Excellent Selectivity for the Neuropeptide Y Y<sub>4</sub> Receptor.
Gleixner J, Gattor AO, Humphrys LJ, Brunner T, Keller M.
J Med Chem (2023) 66 : 13788 -13808
PubMed 37773891 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 6.04 6.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5421880 2 6.04
CHEMBL5429140 2 -
CHEMBL5422869 2 -
CHEMBL5437701 2 -
CHEMBL5435492 2 -
CHEMBL5400627 2 -
CHEMBL5396128 2 -
CHEMBL5430318 2 -
CHEMBL5398948 2 -
CHEMBL5437695 2 -
CHEMBL5428340 2 -
CHEMBL5423253 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5421880 Ki = 912.01 nM 6.04
CHEMBL5396128 Ki > 10000.0 nM -
CHEMBL5429140 Ki > 10000.0 nM -
CHEMBL5422869 Ki > 10000.0 nM -
CHEMBL5422869 Ki > 10000.0 nM -
CHEMBL5437701 Ki > 10000.0 nM -
CHEMBL5437701 Ki > 10000.0 nM -
CHEMBL5435492 Ki > 10000.0 nM -
CHEMBL5435492 Ki > 10000.0 nM -
CHEMBL5400627 Ki > 10000.0 nM -
CHEMBL5400627 Ki > 10000.0 nM -
CHEMBL5421880 Ki > 948.0 nM -
CHEMBL5429140 Ki > 10000.0 nM -
CHEMBL5430318 Ki > 3162.28 nM -
CHEMBL5430318 Ki > 3000.0 nM -
CHEMBL5398948 Ki > 10000.0 nM -
CHEMBL5398948 Ki > 10000.0 nM -
CHEMBL5437695 Ki > 10000.0 nM -
CHEMBL5437695 Ki > 10000.0 nM -
CHEMBL5428340 Ki > 3162.28 nM -
CHEMBL5428340 Ki > 3000.0 nM -
CHEMBL5423253 Ki > 3162.28 nM -
CHEMBL5423253 Ki > 3000.0 nM -
CHEMBL5396128 Ki > 10000.0 nM -