Assay Detail
Functional
CHEMBL5373036
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Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo luminescent assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.83 | 6.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223142 | SCHWEINFURTHIN G | — | 1 | 6.45 |
| CHEMBL220472 | SCHWEINFURTHIN E | — | 1 | 6.40 |
| CHEMBL376007 | SCHWEINFURTHIN F | — | 1 | 6.22 |
| CHEMBL5402401 | — | — | 1 | 6.19 |
| CHEMBL5399392 | — | — | 1 | 6.13 |
| CHEMBL223046 | VEDELIANIN | — | 1 | 6.01 |
| CHEMBL5418635 | — | — | 1 | 5.96 |
| CHEMBL5417439 | — | — | 1 | 5.95 |
| CHEMBL411344 | SCHWEINFURTHIN H | — | 1 | 5.75 |
| CHEMBL5433829 | — | — | 1 | 5.67 |
| CHEMBL5409120 | — | — | 1 | 5.62 |
| CHEMBL5433096 | — | — | 1 | 5.60 |
| CHEMBL5394654 | — | — | 1 | 5.54 |
| CHEMBL5396667 | — | — | 1 | 5.52 |
| CHEMBL5439741 | — | — | 1 | 5.41 |
| CHEMBL5416867 | — | — | 1 | 5.41 |
| CHEMBL5397075 | — | — | 1 | 5.30 |
| CHEMBL5414636 | — | — | 1 | - |
| CHEMBL5397623 | — | — | 1 | - |
| CHEMBL5401329 | — | — | 1 | - |
| CHEMBL515325 | MAPPAIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223142 | SCHWEINFURTHIN G | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL220472 | SCHWEINFURTHIN E | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL376007 | SCHWEINFURTHIN F | IC50 | = | 605.0 | nM | 6.22 |
| CHEMBL5402401 | — | IC50 | = | 647.0 | nM | 6.19 |
| CHEMBL5399392 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL223046 | VEDELIANIN | IC50 | = | 966.0 | nM | 6.01 |
| CHEMBL5418635 | — | IC50 | = | 1095.0 | nM | 5.96 |
| CHEMBL5417439 | — | IC50 | = | 1115.0 | nM | 5.95 |
| CHEMBL411344 | SCHWEINFURTHIN H | IC50 | = | 1793.0 | nM | 5.75 |
| CHEMBL5433829 | — | IC50 | = | 2147.0 | nM | 5.67 |
| CHEMBL5409120 | — | IC50 | = | 2421.0 | nM | 5.62 |
| CHEMBL5433096 | — | IC50 | = | 2533.0 | nM | 5.60 |
| CHEMBL5394654 | — | IC50 | = | 2855.0 | nM | 5.54 |
| CHEMBL5396667 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL5439741 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL5416867 | — | IC50 | = | 3901.0 | nM | 5.41 |
| CHEMBL5397075 | — | IC50 | = | 5002.0 | nM | 5.30 |
| CHEMBL5414636 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5397623 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5401329 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL515325 | MAPPAIN | IC50 | > | 10000.0 | nM | - |