Assay Detail
Binding
CHEMBL5373880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP7 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase TIPARP (CHEMBL2380188) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Quinazoline-2,4(1<i>H</i>,3<i>H</i>)-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, <i>In Vivo</i> Antitumor Activity, and X-ray Crystal Structure Analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.83 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5095043 | ATAMPARIB | 1.0 | 1 | 8.52 |
| CHEMBL5402698 | — | — | 1 | 8.14 |
| CHEMBL5420649 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5095043 | ATAMPARIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5402698 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5420649 | — | IC50 | = | 149.0 | nM | 6.83 |