Assay Detail
Binding
CHEMBL5373947
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Agonist activity at human TLR4 in human HEK-Blue hTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti-blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-Blue hTLR4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diamino Allose Phosphates: Novel, Potent, and Highly Stable Toll-like Receptor 4 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.50 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507938 | — | — | 1 | 9.03 |
| CHEMBL5417929 | — | — | 1 | 8.21 |
| CHEMBL5407900 | — | — | 1 | 8.11 |
| CHEMBL5423611 | — | — | 1 | 8.11 |
| CHEMBL5407887 | — | — | 1 | 7.58 |
| CHEMBL5433813 | — | — | 1 | 7.17 |
| CHEMBL5432710 | — | — | 1 | 7.04 |
| CHEMBL5428754 | — | — | 1 | 6.76 |
| CHEMBL5434803 | — | — | 1 | 6.61 |
| CHEMBL5422378 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507938 | — | EC50 | = | 0.93 | nM | 9.03 |
| CHEMBL5417929 | — | EC50 | = | 6.23 | nM | 8.21 |
| CHEMBL5407900 | — | EC50 | = | 7.86 | nM | 8.11 |
| CHEMBL5423611 | — | EC50 | = | 7.71 | nM | 8.11 |
| CHEMBL5407887 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL5433813 | — | EC50 | = | 68.2 | nM | 7.17 |
| CHEMBL5432710 | — | EC50 | = | 91.9 | nM | 7.04 |
| CHEMBL5428754 | — | EC50 | = | 172.7 | nM | 6.76 |
| CHEMBL5434803 | — | EC50 | = | 246.0 | nM | 6.61 |
| CHEMBL5422378 | — | EC50 | = | 449.0 | nM | 6.35 |