Assay Detail
Binding
CHEMBL5373958
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at TLR4 in human PBMC cells assessed as induction of TNFalpha release incubated for 20 hrs by ELISA
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diamino Allose Phosphates: Novel, Potent, and Highly Stable Toll-like Receptor 4 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.91 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507938 | — | — | 1 | 9.59 |
| CHEMBL5423611 | — | — | 1 | 8.88 |
| CHEMBL5407900 | — | — | 1 | 8.59 |
| CHEMBL5407887 | — | — | 1 | 8.16 |
| CHEMBL5417929 | — | — | 1 | 7.98 |
| CHEMBL5432710 | — | — | 1 | 7.55 |
| CHEMBL5433813 | — | — | 1 | 7.46 |
| CHEMBL5428754 | — | — | 1 | 7.27 |
| CHEMBL5422378 | — | — | 1 | 6.93 |
| CHEMBL5434803 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507938 | — | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL5423611 | — | EC50 | = | 1.33 | nM | 8.88 |
| CHEMBL5407900 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5407887 | — | EC50 | = | 6.88 | nM | 8.16 |
| CHEMBL5417929 | — | EC50 | = | 10.41 | nM | 7.98 |
| CHEMBL5432710 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5433813 | — | EC50 | = | 34.58 | nM | 7.46 |
| CHEMBL5428754 | — | EC50 | = | 53.75 | nM | 7.27 |
| CHEMBL5422378 | — | EC50 | = | 116.27 | nM | 6.93 |
| CHEMBL5434803 | — | EC50 | = | 199.62 | nM | 6.70 |