Assay Detail
Binding
CHEMBL5374064
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Inhibition of Newcastle disease virus APMV-1/chicken/Egypt/13VIR-5009-2/2013 Hemagglutinin-Neuraminidase using 4-MUNeu5Ac as substrate assessed as reduction in neuraminidase activity incubated for 15 mins by spectrofluorometric analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Avian orthoavulavirus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Interplay of Modified Sialic Acid Inhibitors and the Human Parainfluenza Virus 1 Hemagglutinin-Neuraminidase Active Site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.18 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794921 | — | — | 1 | 7.10 |
| CHEMBL514002 | — | — | 1 | 6.96 |
| CHEMBL5430444 | — | — | 1 | 6.82 |
| CHEMBL4300492 | — | — | 1 | 6.75 |
| CHEMBL4756138 | — | — | 1 | 6.75 |
| CHEMBL5401678 | — | — | 1 | 6.22 |
| CHEMBL5398177 | — | — | 1 | 6.05 |
| CHEMBL5406186 | — | — | 1 | 5.96 |
| CHEMBL5414785 | — | — | 1 | 4.96 |
| CHEMBL5412807 | — | — | 1 | 4.21 |
| CHEMBL5406414 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794921 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL514002 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5430444 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4300492 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4756138 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5401678 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5398177 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5406186 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5414785 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5412807 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL5406414 | — | IC50 | = | 186000.0 | nM | - |