Assay Detail
Functional
CHEMBL5374112
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Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 3 days by celltiter-glo 2.0 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Expanding the Chemical Space: New Approach to Cell-Permeable Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.89 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 9.55 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 9.40 |
| CHEMBL5414962 | — | — | 1 | 9.06 |
| CHEMBL5423801 | — | — | 1 | 8.61 |
| CHEMBL5435926 | — | — | 1 | 8.60 |
| CHEMBL4208229 | ASCIMINIB | 4.0 | 1 | 8.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | EC50 | = | 0.28 | nM | 9.55 |
| CHEMBL1171837 | PONATINIB | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5414962 | — | EC50 | = | 0.87 | nM | 9.06 |
| CHEMBL5423801 | — | EC50 | = | 2.47 | nM | 8.61 |
| CHEMBL5435926 | — | EC50 | = | 2.49 | nM | 8.60 |
| CHEMBL4208229 | ASCIMINIB | EC50 | = | 7.59 | nM | 8.12 |