Assay Detail

CHEMBL5374119

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Functional

Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 3 days in the presence of ponatinib by celltiter-glo 2.0 assay

ChEMBL ↗

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Target

K562 (CHEMBL385) ↗

Open DB target context

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Primary target K562

CHEMBL385

Anchored from Assay target.

Protein identity K562

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	K562
Confidence	1 — Organism
Curated By	Autocuration

Target

K562 (CHEMBL385) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Expanding the Chemical Space: New Approach to Cell-Permeable Drugs.

Kargbo RB.
ACS Med Chem Lett (2023) 14 : 1329 -1330
PubMed 37849551 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	9.41	9.41

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4208229	ASCIMINIB	4.0	1	9.41

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4208229	ASCIMINIB	EC50	=	0.39	nM	9.41